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Diazepam belongs to a group of medicines known as benzodiazepines. These medications are used as sedatives, antispasmodics, and to relax tight muscles. Valium is indicated in adults and children from 2 years of age to treat anxiety, tension, and other mental or physical manifestations associated with anxiety.

Valium is indicated in adults to treat: insomnia (sleep disturbances).

Valium should only be used when the disorder is severe, disabling, and causes severe discomfort. Valium is an anxiolytic indicated to combat anxiety and sleep disorders in adults and children. Below you will find information on diazepam dosage and any side effects.

What Is Diazepam Used For?

Diazepam is prescribed in combination with other drugs for insomnia (mainly Diazepam for sleep disorders) and also for patients with alcohol withdrawal symptoms (including the syndrome that causes restlessness, excitement, nervous tension, transitory reactive state, and psychoneurosis)


Urgent short-term symptomatic treatment of:

  • States of strong psychotic excitement and restlessness
  • Severe alcohol withdrawal syndrome (delirium tremens)
  • Tetanus and spastic states of various etiologies
  • Epileptic conditions
  • For pretreatment - preparation for surgical interventions and long diagnostic procedures, e.g., for swallowing echoes.

This medicine should be taken exactly as directed by a doctor.

Doctors prescribe it for anxiety and anxiety, panic disorders, insomnia, alcohol withdrawal, muscle cramps, epilepsy, and anxiety.

  • Feeling of tension
  • Excitement
  • Anxiety issues
  • Sleep disturbances, if at the same time calming down during the day, are desired.

The drug should only be used if the disease is severe and cannot be remedied by other measures in the short term.

  • Calming down before operations or diagnostic procedures
  • Calming down after operations or diagnostic procedures
  • Increased muscle tension

Precautions Before Using Diazepam

Before using Diazepam, tell your doctor if you are diagnosed with the following diseases/conditions or if any of the following applies to you:

  • If you are having a depression feeling (with and without anxiety)
  • If your age is over 60
  • If you have any diseases of the kidneys, liver disease, heart, and lungs
  • If you have any breathing problems
  • Epilepsy or seizures
  • If you have any history of alcohol and drug abuse
  • The presence of suicidal thoughts
  • Changes in the brain, including atherosclerosis (narrowing of the blood vessels)

When given intravenously, Diazepam can slow breathing and heart rate. In rare cases, this can lead to respiratory or cardiac arrest. To avoid this, the drug is administered slowly and in the lowest possible dose of Diazepam.

The attending physician will select the dose of the drug depending on the age and body weight of the child.

  • During the diazepam treatment, alcohol consumption is prohibited.
  • Drivers and people whose activities involve increased concentration do not need to use this medicine during work.
  • Diazepam tablets in children under 14 years of age are only permitted in clearly justified cases; the duration of treatment should be minimal.
  • When taking Valium tablets (even only in therapeutic doses) can lead to the development of habituation and the formation of physical and psychological dependence.
  • Withdrawal from Diazepam should be made gradually with the dose reduction to reduce the risk of withdrawal symptoms. With sharp discontinuation after long-term ingestion or ingestion of high doses, withdrawal symptoms develop (headache and muscle pain, restlessness, worry, confusion, tremor, convulsions), in severe cases - personality alienation, hallucinations, epileptic convulsions.

Dosage & Usage Instructions For Diazepam Tablets

Always use Diazepam exactly as your doctor has told you. If you are not sure about the dose, ask your doctor or pharmacist.

The dose is determined individually by your doctor.

  • Diazepam can be used to treat adults, infants, and children (over 10 kg).
  • The tubes are disposable for rectal administration. The average dose is 0.25-0.5 mg/kg body weight, but this may vary depending on the patient's weight, age, and health.
  • Diazepam Desitin rectal solution is available in unit pack sizes of 5 and Diazepam 10 mg.
  • Because Diazepam Desitin is available in fixed pack sizes of 5 and diazepam 10 mg, you should adjust the dose to the next available dose.

Unless Your Doctor Tells You Otherwise:

  • The recommended dose is normally a 5 mg tube for children aged 1 to 3 years (10-15 kg), one 10 mg tube for children over 3 years (over 15 kg), and two 10 mg tubes for adults. It would be a tube.
  • If no effect is observed after 10 minutes, the above dose can be re-administered in children and an additional Diazepam 10 mg tube in adults.
  • The Diazepam Desitin rectal tube is particularly suitable for clinical, emergency intervention, while it is less suitable for long-term use. The duration of treatment should be limited to a few single doses or, in the case of acute illness, to a few days!
  • However, if long-term treatment is required, the prescribed dose may be re-administered every 12 hours. If the cramps do not go away, consult a doctor.
  • You should only give diazepam Desitin rectal solution to children after careful medical consideration; the duration of treatment should be as short as possible.
  • Elderly and debilitated patients receive no more than half the usual adult dose!
  • In hepatic and renal insufficiency, you should also use a lower dose. In case the risk of diazepam side effects is higher even at normal doses. The treatment should be as short as possible! You should use the lowest possible dose to eliminate symptoms.
  • If used continuously for too long, diazepam dependence may develop, or withdrawal symptoms may occur after discontinuation of the drug.

Diazepam Benefits

Given the use of this drug for more than 50 years, it is considered to be very safe. However, you must make rational use of this remedy, that is, use it properly, in the right dose, and for an appropriate time. Medication can be indicated to relieve symptoms related to the following conditions:

  • Anxiety disorders - anxiety, tension, agitation associated with psychiatric disorders
  • Reflex muscle spasm - picture arises from local trauma
  • Spasticity - increased muscle tone due to neurological changes
  • Alcoholic detoxification - relieves agitation, tremors, hallucinations, and delirium

Diazepam can also be indicated to treat severe pain, tension relief before surgery, epilepsy, or acute seizures.

The medical literature also describes the use of Diazepam as a sedative for patients in the ICU and short-term therapy of spasticity in children (cerebral palsy). Still, according to the American Food and Drug Administration (FDA), these two indications are responsible for the surveillance of drugs and are off-label; that is, they are not included in the package leaflet.

The Most Commonly Reported Side Effects Are:

Tiredness, drowsiness, and muscle weakness, in general, are related to the dose administered. These effects occur predominantly at the beginning of treatment and usually disappear with prolonged administration.

Disorders of the nervous system

Ataxia, dysarthria, slurred speech, headache, tremors, dizziness, decreased alertness. Anterograde amnesia can occur with therapeutic doses, and the risk increases with higher doses. Amnesic effects can be associated with inappropriate behavior.

Psychiatric disorders

Paradoxical reactions such as restlessness, agitation, irritability, disorientation, aggression, nervousness, hostility, anxiety, delusions, anger, nightmares, abnormal dreams, hallucinations, psychoses, hyperactivity, inappropriate behavior, and other known behavioral effects.

These effects are more likely in children and the elderly and, if they occur, you should discontinue the use of the drug. Confusional state, emotional and mood disorders,

Important Considerations For Taking Diazepam

Tell your doctor if you are taking it for the long term or have recently taken or are about to take any other drugs. It applies to any herbal remedies or medications that you bought without a doctor's prescription.

Some drugs can be used with Diazepam, while others can cause side effects when used together.

  • The combination of Diazepam and opioid analgesics (strong pain relievers, substitution medications, and some cough medications) increases the risk of drowsiness, difficulty breathing (respiratory depression), coma, and death. Because of these risks, the combined use of Diazepam and opioid analgesics is possible only in the absence of alternative treatment.
  • Tell your doctor about all the pain relievers you are taking. If you are prescribed Diazepam simultaneously with opioid analgesics, you should use the minimum dose with the minimum duration of therapy. The dose prescribed by the doctor must be carefully observed. It is recommended to inform friends or family about the signs and symptoms like sleep apnea. If you experience these symptoms, you should contact your doctor.

It is very important to tell your healthcare professional if you have recently taken any of the medications listed below.

  • Antidepressants (e.g., fluoxetine, fluvoxamine)
  • Antipsychotics, such as clozapine, olanzapine, zotepine (drugs for the treatment of mental disorders)
  • Antihistamines (for the treatment of allergies)
  • Pain relievers
  • Sedatives
  • Antibacterial drugs such as erythromycin, rifampicin
  • Muscle relaxants (eg, suxamethonium, tubocurarine)
  • Strong pain relievers (such as morphine)
  • Drugs for the treatment of epilepsy (phenobarbital, phenytoin, and carbamazepine, sodium valproate)
  • Drugs to lower blood pressure, diuretics (diuretics), nitrates (to treat heart disease)
  • Antacids (drugs that reduce the acidity of the stomach)
  • Antiviral drugs (atazanavir, ritonavir, delavirdine, efavirenz, indinavir, nelfinavir, saquinavir, zidovudine)
  • Disulfiram (a drug used to treat alcohol dependence)
  • Antifungal drugs (fluconazole, itraconazole, ketoconazole, or voriconazole)
  • Oral contraceptives
  • Corticosteroids
  • Theophylline (a drug used to treat asthma and other breathing disorders)
  • Isoniazid (a drug used to treat tuberculosis)
  • Cisapride (a drug for the treatment of diseases of the gastrointestinal tract)
  • Cimetidine, omeprazole, esomeprazole
  • Levodopa (a drug used to treat Parkinson's disease)
  • Ketamine (used for anesthesia)
  • Lofexidine (a drug to relieve withdrawal symptoms when opioids are stopped)

Taking these drugs in conjunction with Diazepam can affect mental status, cause amnesia, drowsiness, respiratory depression, and a decrease in blood pressure.

Diazepam With Drinks And Alcohol

During treatment, alcohol is unacceptable! Alcohol enhances the sedative effect of Diazepam.

Grapefruit juice can increase the plasma concentration of Diazepam. In the case of elderly patients, patients with cirrhosis or other diseases listed in the Special instructions and precautions section, the sedative effect of Diazepam may increase. Caffeine can reduce the effects of Diazepam.

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Valium is a drug based on the active ingredient Diazepam, belonging to premedication, Anxiolytics, Benzodiazepine antiepileptics, and specifically Benzodiazepine derivatives. Valium Diazepam is used to treat various diseases and pathologies such as Anxiety, Insomnia, Labyrinthitis, Ménière's Disease, and Neurosis.

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What Happens If I Take Too Much?

Intentional or accidental overdosage with Diazepam alone is rarely life-threatening. Overdosing is manifested by the extreme intensification of the product's effects: sedation, muscle relaxation, and the use of Diazepam for sleep or paradoxical excitation.

In most cases, only observation of vital signs is necessary

In severe intoxications, particularly in combination with other centrally acting substances, can cause coma areflexia, cardiorespiratory depression, and apnea requiring appropriate treatment ( ventilation, cardiovascular support, gastric lavage

However, Injectable overdose can cause deep sleep or coma depending on the dose injected.

Symptoms: Central Nervous System CNS depression of various degrees (from drowsiness to coma): marked drowsiness, sluggishness, weakness, inhibition of reflexes, coma; preferably hypotension, respiratory depression.

Treatment: Induction of vomiting and prescription of medical charcoal (when the patient is awake), gastric lavage via the tube (when the patient is unconscious), symptomatic therapy, monitoring of vital parameters, intravenous administration of fluids (for diuresis amplification), artificial respiration is used if necessary. There is no need to use barbiturates when arousal develops. The specific antidote used is the antagonist of the benzodiazepine receptors flumazenil (under stationary conditions). Hemodialysis is not very effective.

What Happens If I Miss A Dose?

Take it as soon as you remember and restart the medicine usage schedule. It is not recommended to take double doses at once to make up for the missed dose. If you always forget to take your medication, use some type of alarm to remember.

Will It Affect My Contraception?

Drug Interactions of Diazepam with the birth control medicines, the contraceptive effect of the pill weaken. Conversely, hormonal contraceptives (pill) can also change, increase or weaken the effectiveness of drugs.

Before taking any medication, you should inform the prescribing doctor about the use of the pill. Whether it may reduce the effectiveness of the pill or doubts like how long does Diazepa take to work? It can also be found in the package insert for the medication. If you are unsure, you should consult a doctor or pharmacist.

I'm Pregnant. Can I Take Diazepam?

To date, there is no information on the safety of this drug during pregnancy. However, as soon as you are aware that you are pregnant, talk to your doctor to assess the relationship between the cost and benefit of continuing or even starting treatment with this medication, mainly because there is a risk of fetal malformation.

However, the continued consumption of this drug during pregnancy can cause conditions like hypotension and a reduction in the baby's temperature. Withdrawal symptoms can also affect the newborn baby.

During labor, Diazepam can affect the fetal heartbeat, influence the suction capacity, among other effects.

Is There A Substitute For Diazepam?

Orfidal, Valium, Diazepam, Sedotime, Xanax, or Trankimazin are some names under which this family of drugs, anxiolytics, and sleeping pills is marketed to be used as a substitute for Diazepam.

Despite their effectiveness and the absence of Diazepam side effects in treatments against anxiety, anxiety, or sleep problems, they often create addictive symptoms with withdrawal syndromes as powerful as those of alcohol.

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